A pilot study for genome wide association study (GWAS) in patients with juvenile idiopathic arthritis (JIA) and their parents
نویسندگان
چکیده
Methods A GWAS using Gene Chip Human Mapping 250K Nsp arrays was performed in 35 trio sets. The patients were grouped into those having oligoarticular or polyarticular JIA and those having SoJIA. Case-control and trio analysis are performed with plink toolset to determine JIA associated SNPs in both patient groups and associated SNPs are prioritized according to their statistical and biological relevance. Enriched genes and pathways within the prioritized SNP list are also analyzed.
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